Tablet Presentation

Each film coated tablet contains:
Vardenafil Hydrochloride Trihydrate USP
eq. to Vardenafil  10 mg

Vardenafil hydrochloride is a phosphodiesterase inhibitor and is used to treat erectile dysfunction. It works by increasing the blood flow to the penis during intercourse and causes erection.
Penile erection is initiated by relaxation of the corpus cavernosum and increases the release of nitric oxide at the nerve endings and activates the guanylate synthesis or increased cyclic guanosine monophosphate in the smooth muscles

Indications

In erectile dysfunction

Mechanism of Action

It is the inhibitor of cyclic guanosine monophosphate i.e. specifically it inhibits phosphodiesterase type 5. Thus, through inhibition the blood flow increases causes erection of penis.

Pharmacokinetics

Absorption- It is absorbed orally
Protein Binding- It is 98% bound to plasma proteins
Metabolism- It is metabolized in liver
Excretion- It is excreted via urine

Side Effects

• Headache
• Heartburns
• Nausea
• Dizziness
• Stomach upset
• Runny nose
• Flushing in neck

Contraindications

• Contraindicated in leukaemia
• Contraindicated in sickle anemia

Drug Interactions

• Amlodipine
• Amiodarone
• Duloxetine
• Aspirin
• Losartan
• Metoprolol
• Lisinopril

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